PhD Studentship - Targeting myosin for heart disease: a structure-based approach to design conformation-selective modulators

Queen Mary University of London, in collaboration with King’s College London

Closing date 31st January 2019

The aim of the project is to design and test small molecules that can either inhibit or activate cardiac myosin, a key component of the molecular machinery involved in heart contraction. A combined computational/experimental approach will be used, which will involve the use of molecular dynamics, molecular docking, virtual screening and in vitro biophysical techniques. 

Applications are welcome from outstanding students with, or expecting to obtain, a first or upper-second class honours degree in Chemistry, Pharmaceutical Chemistry, Biochemistry, Physics, Biophysics or related disciplines. A masters degree is desirable. Previous experience in molecular modelling/simulation is essential, previous experience in computer programming and/or experimental biophysical techniques is a plus.

The studentship is funded by EPRSC and will cover tuition fees and an annual tax-free maintenance allowance at the Research Council rate (£16,777 in 2018/19) for 3.5 years. UK students, and EU students who have been ordinarily resident in the UK for at least 3 years are normally eligible for full EPSRC funding.

For more information: 

https://www.qmul.ac.uk/sbcs/postgraduate/phd-programmes/projects/display-title-649759-en.html

https://www.findaphd.com/phds/project/targeting-myosin-for-heart-disease-a-structure-based-approach-to-design-conformation-selective-modulators/?p105203

Before submitting a formal application online, please contact Dr. Fornili (a.fornili@qmul.ac.uk) and include your CV, your academic transcripts, a cover letter explaining eligibility and interest in the project and the contact details of two academic referees. The deadline for formal applications is on the 31st of January 2019.

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